Manipulating the Type 1 vs Type 2 Balance in Type 1 Diabetes
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Immunologic Research
- Vol. 30 (3) , 309-326
- https://doi.org/10.1385/ir:30:3:309
Abstract
Virus infections cause a strong inflammatory reaction that is dominated by the expression of type 1 cytokines and chemokines. Such an aggressive immune response by the host is necessary to eliminate intracellular pathogens. However, because of this shift in the type 1 vs type 2 balance of the immune response, virus infections are potential candidates for triggering autoimmune diseases, such as type 1 diabetes (T1D), herpes stromal keratitis, or multiple sclerosis (MS). In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated.Keywords
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