The stimulation of steroidogenesis by corticotrophin: the role of intracellular regulatory peptides and proteins

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Abstract
Several aspects of the intracellular mechanisms involved in the steroidogenic response of adrenocortical tissue to stimulation by corticotrophin remain uncertain. As in other systems, the peptide interacts with a specific membrane receptor (see e.g. Buckley & Ramachandran, 1981) and the subsequent activation of adenylate cyclase is one of the classical examples of this system in the literature (Grahame-Smith, Butcher, Ney & Sutherland, 1967), although, because of the incomplete correlation between steroid and cyclic AMP output, other mechanisms for intracellular signal transduction are not necessarily excluded (e.g. Yanagibashi, Kamiya, Lin & Matsuba, 1978; Kojima, Kojima & Rasmussen, 1985; but see also Wong, O'Brien & Schimmer, 1986). Events subsequent to the activation of adenylate cyclase are less clear. Certainly there follows activation of cyclic AMP-dependent protein kinases and, consequently, protein phosphorylation (e.g. Koroscil & Gallant, 1981; Ahrens, Aiyar & Sharma, 1986; Wong et al. 1986) but how this in turn leads to

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