CHEMOTHERAPY OF ADVANCED L1210 LEUKEMIA WITH PLATINUM COMPOUNDS IN COMBINATION WITH OTHER ANTITUMOR AGENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 61  (3) , 445-450
Abstract
Six antitumor Pt compounds were used in combination with cyclophosphamide (CY) plus 1 of 5 other antitumor drugs in the treatment of advanced (day 3) L1210 leukemia in (C57BL/6 .times. DBA/2)F1 mice. The combination of CY with a Pt compound yielded a collective cure rate of 24%. The addition of a 3rd drug to the dual regimen increased the collective cure rate to 55%. The most effective drugs when used in combination with Pt compounds plus CY were, in increasing order to efficacy, 5-fluorouracil, hydroxyurea and methotrexate. No toxic deaths occurred with any regimen at the dose levels used.

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