Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue
- 12 November 2001
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 4 (12) , 1163-1164
- https://doi.org/10.1038/nn762
Abstract
We show that iris tissue in the adult rat eye, which is embryonically related to the neural retina, can generate cells expressing differentiated neuronal antigens. In addition, the Crx gene transfer induced the specific antigens for rod photoreceptors in the iris-derived cells, which was not seen in the adult hippocampus-derived neural stem cells. Our findings demonstrate a remarkable plasticity of adult iris tissue with potential clinical applications, as autologous iris tissue can be feasibly obtained with peripheral iridectomy.Keywords
This publication has 14 references indexed in Scilit:
- Retinal Stem Cells in the Adult Mammalian EyeScience, 2000
- Unique retina cell phenotypes revealed by immunological analysis of recoverin expression in rat retina cellsJournal of Neuroscience Research, 1999
- Widespread Integration and Survival of Adult-Derived Neural Progenitor Cells in the Developing Optic RetinaMolecular and Cellular Neuroscience, 1998
- Crx, a Novel Otx-like Paired-Homeodomain Protein, Binds to and Transactivates Photoreceptor Cell-Specific GenesNeuron, 1997
- Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor DifferentiationCell, 1997
- The Adult Rat Hippocampus Contains Primordial Neural Stem CellsMolecular and Cellular Neuroscience, 1997
- Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.Proceedings of the National Academy of Sciences, 1996
- Cell fate determination in the vertebrate retina.Proceedings of the National Academy of Sciences, 1996
- A SIMPLE AND EFFICIENT METHOD FOR PURIFICATION OF INFECTIOUS RECOMBINANT ADENOVIRUSJapanese Journal of Medical Science and Biology, 1994
- Monoclonal antibodies which recognize different cell types in the rat retinaNature, 1980