Delayed effects of radiation on the human central nervous system

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Abstract
Two cases of delayed effects of radiation on the central nervous system of man are reported. One demonstrates the rare early delayed reaction which occurs approximately 3 months after radiation. The lesions resemble most closely the plaques of acute multiple sclerosis and are not associated with degenerative vascular changes. This patient probably represents an extreme of the early delayed reaction reported by Scholz1 2 in dogs. There is clinical evidence suggesting that some degree of damage of this type occurs more frequently than has been suspected. The other patient had the late delayed reaction in which there are marked degenerative vascular alterations and severe destruction of the white matter with little cortical involvement. This patient is an extreme example of the well-documented late delayed effects of radiation and is presented for contrast with the patient in case 1. The presence of hypertrophic neurons in the irradiated cortex is a new and unexplained finding.

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