Protein dynamics and function: Insights from the energy landscape and solvent slaving

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Abstract
Protein motions are complex and a good way to describe them is in terms of a very high‐dimensional conformation space. We give here a simple explanation of the conformation space and the energy landscape, the conformational motions and protein reactions, based on an analogy to a traffic problem. The analogy provides insight into the slaving of protein processes to bulk solvent fluctuations, in both the native and unfolded states.

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