Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
Open Access
- 14 January 1999
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 79 (3-4) , 451-455
- https://doi.org/10.1038/sj.bjc.6690070
Abstract
Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.Keywords
This publication has 42 references indexed in Scilit:
- Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor.Journal of Clinical Investigation, 1997
- How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseasesEuropean Journal Of Cancer, 1996
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisPublished by Elsevier ,1996
- Interleukin‐8 and de novo mammalian angiogenesisCell Proliferation, 1996
- Ultrastructural immunogold localization of tumor necrosis factor-α to the cytoplasmic granules of rat peritoneal mast cells with rapid microwave fixationJournal of Allergy and Clinical Immunology, 1994
- Bone marrow angiogenesis and progression in multiple myelomaBritish Journal of Haematology, 1994
- Antiangiogenic Effect of Heparin and Other Sulphated Glycosaminoglyycans in the Chick Embryo Chorioallantoic MembraneBasic & Clinical Pharmacology & Toxicology, 1991
- Inhibition of Angiogenesis with Combination Treatments of Angiostatic Steroids and SuraminInternational Journal of Radiation Biology, 1991
- Effects of Exogenous Heparin on the Vasculogenesis of the Chorioallantoic MembraneCells Tissues Organs, 1987
- Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial CultivationScience, 1983