Amidoselenation of olefins via hydroxyselenation: reactions using nitriles in reagent quantity and the synthesis of β-(acrylamido)alkyl phenyl selenides
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 343-347
- https://doi.org/10.1039/p19860000343
Abstract
Limitations in a previously reported amidoselenation reaction have been overcome by the use of β-hydroxyalkyl phenyl selenides, (1) and (2), as starting materials; these when treated with nitriles (1–5 equiv.) in dichloromethane in the presence of trifluoromethanesulphonic acid afforded the β-amidoalkyl phenyl selenides (3) or (4) in good yield. Further, side reaction brought about by hydrogen chloride have been prevented; thus (1) and (2) in the presence of acid afforded the β-(acrylamido)alkyl phenyl selenides (5) or (7), free from side products.Keywords
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