The Lutropin/Choriogonadotropin Receptor… 4 Years Later*

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Abstract
I. Introduction IN 1989 we published a review in this journal in which we summarized, criticized, and attempted to reconcile the conflicting data that existed on the structure of the mammalian LH/CG receptor (1). Based on our analysis of the existing data we concluded that the LH/CG receptor was composed of a single polypeptide chain. Since that review was published, complementary DNAs (cDNAs) for the LH/CG receptor from several species have been cloned, sequenced, and expressed, conclusively establishing that this receptor is indeed a single polypeptide chain (2–5). The cloning of the cDNAs for the LH/CG receptor has also generated new knowledge and experimental tools that are rapidly being used to probe novel aspects of the functions and regulation of this important receptor. Since the studies leading to the cloning of the first cDNA for the LH/CG receptor have been recently summarized (6), this review will only briefly touch on this aspect and focus mainly on what has been learned since the initial cloning was published.

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