Effect of phenobarbital on the disposition of intravenous theophylline
- 1 September 1977
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 22 (3) , 336-339
- https://doi.org/10.1002/cpt1977223336
Abstract
The disposition of intravenous doses of theophylline was determined in normal male subjects before and after treatment with phenobarbital for 2 wk. Although there was some variation in disposition of the 2 drugs, there were no significant effects of phenobarbital on theophylline kinetics. We conclude that theophylline dosage need not be altered during concomitant administration of phenobarbital.This publication has 5 references indexed in Scilit:
- Phenobarbital-induced drug metabolism in manToxicology and Applied Pharmacology, 1976
- Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in manClinical Pharmacology & Therapeutics, 1976
- Effect of smoking on theophylline dispositionClinical Pharmacology & Therapeutics, 1976
- Relationship of urinary metabolites of theophylline to serum theophylline levelsClinical Pharmacology & Therapeutics, 1976
- THEOPHYLLINE METABOLISM BY RAT-LIVER MICROSOMAL SYSTEM1976