Expression ofFv-4r allele in hematopoietic cells from g mice resistant to friend leukemia virus

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Abstract
G mice carrying the Fv‐4 resistant allele supported virus growth neither at an early nor a later (Kai et al., 1976) stage of infection with NB‐tropic FLV. This resistance could not be abolished by treatment of G mice with cyclophosphamide or cortisone acetate. By bone‐marrow or spleen‐cell transplantation into irradiated mice, the resistance of G mice could be transferred to Fv‐4‐susceptible mice. Conversely, transfer of bone‐marrow or spleen cells of Fv‐4‐susceptible mice rendered G mice susceptible. It could be concluded that, as assessed by the virus content in the spleen, helper LLV grows mainly in radiosensitive, bone‐marrow‐derived cells, and the Fv‐4 gene is expressed in these cells.