Studies on the Metabolism ofd-Limonene (p-Mentha-1,8-diene): I. The Absorption, Distribution and Excretion ofd-Limonene in Rats
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 4 (2) , 77-84
- https://doi.org/10.3109/00498257409049347
Abstract
1. The absorption, distribution and excretion of d-limonene were investigated in rats using the 14C-labelled compound. 2. The highest concentration of radioactivity in blood was obtained 2 h after oral administration of [14C]d-limonene and most occurred in the serum fraction. Radioactivity in the tissues reached maximum 1 or 2 h after administration. Radioactivity in liver, kidney and blood was higher than in other tissues, but was negligible 48 h after administration. An autoradiographic study confirmed these findings of tissue distribution. 3. About 60% of administered radioactivity was recovered from urine, 5% from faeces and 2% from expired CO2 within 48 h. In bile duct cannulated rats, about 25% of the dose was excreted in bile within 24 h.Keywords
This publication has 2 references indexed in Scilit:
- Studies on the Metabolism ofd-Limonene (p-Mentha-1,8-diene): II. The Metabolic Fate ofd-Limonene in RabbitsXenobiotica, 1974
- Dissolution of human gallstoneSurgery Today, 1972