Differences in Stability of Antigen-Antibody Complexes Formed with Poliovirus and Acute and Convalescent Phase Human Sera
Open Access
- 1 October 1959
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 83 (4) , 405-410
- https://doi.org/10.4049/jimmunol.83.4.405
Abstract
Summary: The relative stability of antibody-poliovirus complexes was studied, comparing acute and convalescent phase human sera. At pH 7.5, the rate of reactivation of virus upon dilution of serum-virus mixtures was found to be higher with acute phase sera than with convalescent phase antibody. At pH 4.0, the rate is increased, allowing in 1 hr at 37°C for up to 99% reactivation with acute and up to 23% with convalescent type sera.Keywords
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