CEREBRAL METABOLISM IN FAT FED DOGS

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Abstract
The arterio-venous differences in ketone bodies, glucose, O3 and CO2 were detd. in 11 dogs fed fat for from 2-6 wks. The blood was drawn simultaneously from the femoral artery and the superior longitudinal sinus. The mean differences for ketone bodies (as B-hydroxybutyric) were 0.57 mg./100 ml. (standard error [plus or minus]0.12). for O2 8.55 vol. %, and for glucose 9.0 mg. per 100 ml. The mean R.Q. was 1.01 ([plus or minus]0.029). These results indicate (1) that the brain of the dog which has been fed fat for a sufficient time not only develops ketosis but also becomes habituated to the ketotic state and does not burn acetone bodies, (2) that the brain does not burn fat directly, and (3) that O2 and glucose utilizations, in terms of mg./lOO ml. of blood, are not detectably different from those of normally fed animals.

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