Activation of epileptogenic foci by hyperosmolality

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Abstract
Hypertonic glucose or mannitol was found to increase the probability of occurrence of recurrent electrical seizures in the region of a penicillin spike focus in the striate cortex of unanesthetized cats. This experimental phenomenon resembles a recently described clinical syndrome of status epilepticus, focal type, accompanying diabetic hyper-glycemia without acidosis. Serum hyperosmolality and brain dehydration were a sufficient explanation, in both the experimental and clinical material, for the induction of seizures, given the condition of a potentially epileptogenic process in some cortical area. Clinical conditions characterized by osmotic dehydration of other etiology may show recurrent focal seizures if a spike-producing focus is present in the cortex.

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