Fluoride, Fluoride Resistance and Glycolysis in Cultured Cells
- 1 September 1978
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 43 (3) , 240-245
- https://doi.org/10.1111/j.1600-0773.1978.tb02260.x
Abstract
Long-term (several years) exposure to fluoride induced decreased production of lactate in cultured, fluoride resistant LS [rat (Lewis) sarcoma cells]. In intact, sensitive cells, 6 mM NaF had no effect on glycolysis, whereas in homogenates, from both resistant and sensitive cells, lactate production was blocked by 6 nM NaF, indicating the cell membrane to be a barrier to fluoride. A lower intracellular rather than extracellular fluoride concentration was found in the sensitive cell with a ratio of 0.4, whereas fluoride resistant cells excluded fluoride from their intracellular milieu.Keywords
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