Effects of cystamine and cysteamine on the peroxidation of lipids and the release of proteins from mitochondria
- 1 October 1966
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 101 (1) , 37-41
- https://doi.org/10.1042/bj1010037
Abstract
Cystamine slightly stimulated the peroxidation of lipids in mitochondria. Maximal effects were obtained at low concentrations (0.5 m[image]). Cysteamine, when allowed to autoxidize, had much stronger effects than cystamine. Cysteamine and GSH [reduced glutathione] did not induce peroxidation when their autoxidation was counteracted. When kept reduced, cysteamine prevented the ascorbate-induced peroxidation of lipids. GSH was less efficient. Cysteamine as well as cysteamine prevented the loss of proteins from mitochondria induced by ascorbate, whereas cadaverine, GSSG [oxidized glutathione] and GSH were ineffecient.This publication has 24 references indexed in Scilit:
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