Effect of EGTA on Protein Release and Cyclic AMP Accumulation in Rat Parotid Gland

1 December 1973

journal article
Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology

Vol. 51 (12) , 997-1001
https://doi.org/10.1139/y73-152

Abstract

An attempt was made to determine whether accumulation of cyclic AMP (cAMP) was essential for epinepnrine-stimuiated secretion of protein from the rat parotid gland in vitro. EGTA (10⁻² M) did not inhibit secretion but did reduce cAMP accumulation by 80% suggesting that this nucleotide may not be an essential intermediate in the epinephrine-stimuiated secretion process.

Keywords

PROTEIN
EPINEPHRINE
ACCUMULATION
CYCLIC AMP
EGTA
ATTEMPT
MADE
EPINEPNRINE