Nucleotide sequences of MHC class I introns 1, 2, and 3 in humans and intron 2 in nonhuman primates
- 1 June 1996
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 47 (6) , 498-511
- https://doi.org/10.1111/j.1399-0039.1996.tb02592.x
Abstract
HLA‐class I genes are the most polymorphic genetic system yet known. The polymorphic substitutions are mostly located in exon 2 and 3, encoding α1 and α2 domains, respectively, which are involved in peptide binding and T cell receptor interaction. In this study, we present the sequences of the introns neighboring the polymorphic exons in humans with few examples from non‐human primates. In general, intron sequences are found to be less polymorphic than the adjacent exons, displaying numerous locus‐specific and group‐specific sites. These sequences will provide important information for developing DNA based typing strategies for HLA‐class I alleles.Keywords
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