The Effect of Administration of Pantothenic Acid on the Histopathology of the Filtrate Factor Deficiency State in Rats

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Abstract
The adrenal lesions, abnormal testicular function, and cartilage hypoplasia occurring in rats fed on a diet deficient in the "filtrate factor" are markedly affected by supplementing the diet with 100 [gamma] of pantothenic acid daily. Arrest and repair of adrenal lesions occur, testicular function is improved, and skeletal growth is accelerated. Rats may develop a partial or complete adrenal cortical insufficiency on the deficient diet.

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