ADRENAL FUNCTION IN A PREGNANT BILATERALLY ADRENALECTOMIZED WOMAN*

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Abstract
A case is presented of successful pregnancy in a patient who had undergone bilateral adrenalectomy for Cushing's syndrome. Studies of plasma and urinary steroids were performed before and after treatment during pregnancy and post partum. The observations suggest that the increased urinary excretion of aldosterone and the increased adrenal “responsiveness” to corticotropin seen in the normal pregnant subject require the presence of an intact adrenal gland, and are not mediated through the placenta. The increase in the half-life of hydrocortisone in pregnancy is dependent upon extra-adrenal factors.

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