Regulation of Plasma Ferritin by the Isolated Perfused Rat Liver

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Abstract
The isolated perfused rat liver was used to investigate the regulation of plasma ferritin in normal, Fe-deficient and Fe-overloaded states. 125I-labeled and nonlabeled rat liver ferritins were rapidly cleared from the perfusion circuit with a half-life of .apprx. 30 min. Perfusion of livers from normal, Fe-loaded or Fe-deficient rats with blood obtained from normal, Fe-loaded or Fe-deficient rats showed that the liver takes up plasma ferritin and releases ferritin into the perfusate to achieve a perfusate ferritin level appropriate to the Fe stores of the animal from which the liver was taken. The liver evidently is capable of uptake and release of ferritin; within the liver there resides a mechanism which maintains circulating ferritin concentrations at a level appropriate to body Fe stores.

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