Disparate Effects of Carvedilol Versus Metoprolol Treatment of Stroke-Prone Spontaneously Hypertensive Rats on Endothelial Function of Resistance Arteries

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Abstract
In human hypertension, blockade of β-adrenoceptors does not improve resistance artery structure or endothelial dysfunction. We tested in hypertensive rats the hypothesis that carvedilol, a β-blocker with antioxidant properties, would improve endothelial dysfunction, whereas the β1-selective blocker, metoprolol, would not. Twenty-week-old SHRSP were treated orally for 10 weeks with carvedilol (50 mg/kg/day) or metoprolol (100 mg/kg/day), with or without hydralazine (25 mg/kg/day), the latter because neither β-blocker was a very effective blood pressure-lowering agent in this model. Mesenteric arteries (lumen, −7

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