FURTHER STUDIES ON THE EFFECT OF CADMIUM ON THE PROSTATE GLAND—IIABSENCE OF PROSTATIC CHANGES IN MICE GIVEN ORAL CADMIUM SULPHATE FOR EIGHTEEN MONTHS

1 February 1975

journal article
Published by Oxford University Press (OUP) in Annals of Work Exposures and Health

Vol. 17, 213-220
https://doi.org/10.1093/annhyg/17.3-4.213

Abstract

This paper describes the third in a series of experiments designed to investigate the effects of cadmium on the prostate gland. Male Swiss mice were given cadmium sulphate (3CdSO₄.8H₂O) in aqueous solution by stomach tube. The maximum dose given was 4·0 mg 3CdSO₄.8H₂O per kg body weight each week for eighteen months. Neither at this dose level nor at two lower levels were lesions of a ncoplastic or preneoplastic nature seen in the genitourinary tract generally or in the prostate gland in particular. No other effects on the mice attributable to cadmium were observed. The results of the present experiment and those of the two previous experiments in the series are discussed in the light of equivocal evidence of an effect of exposure to cadmium on the incidence of cancer of the prostate in man.

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