Myasthenia Gravis Associated with Diphenylhydantoin Therapy For Epilepsy
- 1 May 1974
- journal article
- case report
- Published by Cambridge University Press (CUP) in Canadian Journal of Neurological Sciences
- Vol. 1 (2) , 127-129
- https://doi.org/10.1017/s0317167100019697
Abstract
SUMMARY: A young woman with epilepsy developed myasthenic symptoms while taking diphenylhydantoin. The clinical, electromyographic and pharmacologic findings were consistent with myasthenia gravis. Symptoms of myasthenia ceased on withdrawal of the drug, and recurred on readministration, with little apparent relationship to serum phenytoin levels. This unusual effect is discussed with reference to the known effects of diphenylhydantoin at the neuromyal junction.Keywords
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