Effets cardio-vasculaires comparés des inhibiteurs de la mono-amine-oxydase. Effets pharmacologiques. Action sur la dynamique et le métabolisme cardiaque

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Abstract
The purpose of this work is to compare the pharmacological and biochemical effects of some monoamine oxidase inhibitors: to confront the various hypotheses put forth concerning their mechanism of action; and to propose a metabolic concept explaining the effect of these inhibitors on the heart. In the first part we discuss the influence of monoamine oxidase inhibitors on arterial pressure, cardiac output and the volume of the systolic pulse wave the peripheral vascular resistance, the coronary flow, coronary vascular resistance and the O2 consumption of the left ventricle. All these observations make one think that the monoamine oxidase inhibitors have a metabolic effect on cardiodynamics. In the second part the effect of monoamine oxidase inhibitors on cardiac metabolism is studied. Tersavid, Niamid (nialamide) and PC 603 are the only inhibitors which significantly reduce left ventricular O2 consumption. Marsilid (iproniazid) produces an important but not significant reduction. Marplan, on the contrary, increases the O2 consumption. In the third part the preventive action of these inhibitors against anoxia produced by respiratory arrest, localized ischemia and acute coronary vaso-constriction is studied. The fourth part is devoted to the study of the relationships between the chemical structure and the effects on the cardiovascular system. In conclusion, we discuss the different mechanisms which can be considered in order to explain the effects of the monoamine oxidase inhibitors on the hypoxia of the myocardium and peripheral musculature.