Ionic Interaction with Bone Mineral. III. Reversible Calcium Exchange with Bone Powder

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Abstract
The curve describing the uptake of Ca45 by bone powder or by synthetic hydroxyapatite shows an initial rapid fall in radioactivity of solution followed by a monoexponential decline at a slower rate. Wash-out experiments were performed on the labelled crystals before and during the period of monoexponential fall by resuspending the crystals, collected by filtration, in medium free of isotope. More than 80% of Ca45 could be removed from the crystal phase by this procedure regardless of the period of labelling. "Back-diffusion" of isotope from bone into solution has been reported operative only at a certain region of the uptake curve; the present studies contradict this interpretation.

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