Subpopulations of Human T Lymphocytes

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Abstract
Peripheral blood from 4 patients with progeria and their family members and 2 patients with Werner''s syndrome were analyzed for the proportion of total T cells and T cells with receptors for IgM (T.mu.) or IgG (T.gamma.). In 3 patients proportions of T.mu. cells were within the range for age- and sex-matched controls. One patient had significantly lower proportions of T.mu. cells when compared to age- and sex-matched controls. The proportions of T.gamma. cells were increased in 2 and were within the range for normal controls in the remaining 2 patients. When data were analyzed with regard to T.mu./T.gamma. ratios, 3 of 4 patients exhibited ratios lower than the lowest limit observed in age- and sex-matched controls. Family members in all 4 families exhibited patterns of T.mu. and T.gamma. cells similar to that seen in the patient. Both patients with Werner''s syndrome had high proportions of T.gamma. cells, resulting in low T.mu./T.gamma. ratios.

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