Studies on Species Specificity

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Abstract
Summary: Species-specific antigens were described which are present in fractions of mammalian tissues prepared by extraction at 100°C. followed by precipitation by ethanol (BE fractions). Interspecies cross-reactions were rather weak; they were more pronounced in closely related species, e.g., man and Rhesus monkey, than in distant species. Rabbit antisera to BE fractions of human, bovine, porcine and equine origin were used as reagents for identification of the species origin of various blood, urine and tissue specimens. Specimens to be studied were at first processed to obtain the BE fractions, and then they were tested against the antisera. Correct identification of the species origin could be made in testing autoclaved blood, decayed tissues and blood, and processed food products. The antigens under investigation were not destroyed by digestive enzymes and could be demonstrated in the feces of rats fed with bovine and porcine liver. The possible application of the described methods in forensic medicine was discussed.

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