FURTHER STUDIES IN THE INACTIVATION OF PEPSIN
- 1 August 1916
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. XVIII (2) , 228-234
- https://doi.org/10.1001/archinte.1916.00080150093004
Abstract
In a previous communication by one of us1it was demonstrated that sodium chlorid will prevent pepsin in aqueous solution from digesting protein. It was further pointed out that the inhibition of pepsin by sodium chlorid is permanent, that is, the subsequent addition of hydrochloric acid fails to reactivate the ferment. This phenomenon of pepsin inhibition may be prevented by dissolving the ferment in dilute hydrochloric acid. The inactivation of pepsin by sodium chlorid suggested the desirability of studying the action of various other salts to ascertain, if possible, whether this phenomenon was specific or whether it was common to many salts. Before this was attempted, however, a somewhat more detailed quantitative study of the action of sodium chlorid itself was made. The results from this study are shown in Table 1. Here it was found that the inhibitory effect of sodium chlorid is aThis publication has 0 references indexed in Scilit: