GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE ACTIVITY IN CARCINOGEN-INDUCED EPITHELIAL LESIONS OF RAT-KIDNEY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 73  (4) , 543-548
Abstract
A marked decrease of .gamma.-glutamyl transpeptidase [GGT] activity in rat renal cell neoplasms and preneoplastic tubular lesions induced by exposure to carcinogens was demonstrated. Rat renal cell tumorigenesis might require a transformation to fetal characteristics in enzymatic activity such as is found in rat liver cell tumorigenesis, although the nature of the change in activity is quite different. Persistence of weak GGT activity of renal tubular cells during tumorigenesis may provide a useful histoenzymatic marker and indicate a biological reversion of the membrane function during the process of renal cell tumorigenesis.