ISLET CELL ADENOMATOSIS - A REPORT OF 2 CASES AND REVIEW OF THE LITERATURE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 105  (4) , 198-202
Abstract
Two human cases of nesidioblastosis in infants with severe neonatal hypoglycemia were studied by immunocytochemical staining and EM examination of the resected pancreata. There was a diffuse proliferation of insulin-, glucagon- and somatostatin-producing cells in both cases. A 0.6 cm adenoma present in 1 case consisted of insulin-, glucagon- and somatostatin-producing cells in close proximity to ductal cells. Pancreatic polypeptide-producing cells were also identified by EM. Some adenomas apparently consist of mixed islet cell types, although severe hypoglycemia is usually the major initial symptom.