Least dissipation cost as a design principle for robustness and function of cellular networks
- 27 March 2008
- journal article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 77 (3) , 031922
- https://doi.org/10.1103/physreve.77.031922
Abstract
From a study of the budding yeast cell cycle, we found that the cellular network evolves to have the least cost for realizing its biological function. We quantify the cost in terms of the dissipation or heat loss characterized through the steady-state properties: the underlying landscape and the associated flux. We found that the dissipation cost is intimately related to the stability and robustness of the network. With the least dissipation cost, the network becomes most stable and robust under mutations and perturbations on the sharpness of the response from input to output as well as self-degradations. The least dissipation cost may provide a general design principle for the cellular network to survive from the evolution and realize the biological function.Keywords
This publication has 28 references indexed in Scilit:
- Single molecule dynamics and statistical fluctuations of gene regulatory networks: A repressilatorThe Journal of Chemical Physics, 2007
- Self-regulating gene: An exact solutionPhysical Review E, 2005
- Integrative Analysis of Cell Cycle Control in Budding YeastMolecular Biology of the Cell, 2004
- The yeast cell-cycle network is robustly designedProceedings of the National Academy of Sciences, 2004
- Network Motifs: Simple Building Blocks of Complex NetworksScience, 2002
- Specificity and Stability in Topology of Protein NetworksScience, 2002
- A Genomic Regulatory Network for DevelopmentScience, 2002
- Network dynamics and cell physiologyNature Reviews Molecular Cell Biology, 2001
- The large-scale organization of metabolic networksNature, 2000
- Ultrasensitivity in the mitogen-activated protein kinase cascade.Proceedings of the National Academy of Sciences, 1996