Solid phase microextraction coupled to capillary electrophoresis

Abstract
An on-column interface, coupling the solid phase microextraction (SPME) sampling technique with capillary electrophoresis (CE), has been constructed. This interface facilitates the direct insertion of a thin silica fiber into the inlet end of a separation capillary and, therefore, the zero-dead volume connection requirement for hyphenation between SPME and CE is fully realized. The performance of the interface was evaluated by SPME–CE analysis of the priority pollutant phenols using a laboratory-made 40 µm od poly(acrylate) (PA)-coated silica fiber connected to a 75 µm id separation capillary. The results clearly demonstrate that the interface is effective for on-line coupling SPME with CE.

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