Ethylene oxide dose and dose‐rate effects in the mouse dominant‐lethal test

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Abstract
In the dose‐response study, male mice were exposed by inhalation to ethylene oxide (EtO) for 4 consecutive days. Mice were exposed for 6 hr per day to 300 ppm, 400 ppm, or 500 ppm EtO for a daily total of 1,800, 2,400, or 3,000 ppm hr (total exposures of 7,200, 9,600 and 12,000 ppm hr), respectively. In the dose‐rate study, mice were given a total exposure of 1,800 ppm hr per day, also for 4 consecutive days, delivered either at 300 ppm in 6 hr, 600 ppm in 3 hr, or 1,200 ppm in 1.5 hr. Quantitation of dominant‐lethal responses was made on matings involving sperm exposed as late spermatids and early spermatozoa, the most sensitive stages to EtO. In the dose‐response study, a dose‐related increase in dominant‐lethal mutations was observed, the dose‐response curve proved to be nonlinear. In the dose‐rate study, increasing the exposure concentrations resulted in increased dominant‐lethal responses.

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