Combined Surgical and Radiation Injury The Effect of Timing of Wounding and Whole Body Gamma Irradiation on 30 Day Mortality and Rate of Wound Contracture in the Rodent

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Abstract
The determination of the effect of timing of whole body irradiation and wounding on the mortality and rate of wound contractare was studied. Rats were wounded by excision of a dorsal piece of skin 4 days before, 1 day before, 1 day after and 4 days after exposure to 875 R. The mortality of non-wounded irradiated animals and animals wounded 4 days prior to or 1 day following irradiation was similar. Mortality of animals wounded 1 day prior to irradiation was diminished, and of those wounded 4 days following irradiation greatly increased. In animals wounded prior to irradiation there was a minimal transient cessation of wound contracture; in those wounded after irradiation there was an immediate and greater interference with wound contracture, particularly in animals wounded 4 days following irradiation.