N‐Acetylcysteine for the Treatment of Clove Oil Induced Fulminant Hepatic Failure: Case Report and Review of the Literature

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Abstract
We present a 3‐month‐old female who developed fulminant hepatic failure after ingesting less than 8 mL of clove oil. Initial treatment involved gastrointestinal decontamination, supportive measures, and admission to hospital. She subsequently developed fulminant hepatic failure and was treated with intravenous N‐acetylcysteine (N‐AC) according to a protocol used for acetaminophen poisoning. Over the next 72h her liver synthetic function and clinical status improved, and she made a complete recovery. Previous reported cases of clove oil toxicity and the potential role of N‐AC therapy are reviewed.