AIDS- and non–AIDS-related PML association with distinct p53 polymorphism
- 8 February 2000
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 54 (3) , 743
- https://doi.org/10.1212/wnl.54.3.743
Abstract
Article abstract A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. These findings indicate that frequencies of non–AIDS- and AIDS-related PML differ markedly but p53 polymorphisms may influence the occurrence of PML in both groups.Keywords
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