Diarrhea in Cecectomized Rabbits Induced by Staphylococcal Enterotoxin.
- 1 October 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 117 (1) , 115-118
- https://doi.org/10.3181/00379727-117-29510
Abstract
Summary Cecectomized rabbits (removal of appendix and all of cecum except proximal 3 segments) were challenged intravenously with highly purified staphylococcal entero-toxin. Diarrhea was induced in cecectomized rabbits in doses ineffective for normal rabbits. Average latency was 1¾ hours with recovery from diarrhea within 24 hours. Successive weekly injections of enterotoxin resulted in development of resistance. Pre-treatment of cecectomized rabbits with atro-pine or pyribenzamine gave definite but incomplete protection against enterotoxin-in-duced diarrhea.Keywords
This publication has 1 reference indexed in Scilit:
- Enhancement of Bacterial Endotoxin Lethality by Staphylococcal EnterotoxinThe Journal of Infectious Diseases, 1964