Anti-anabolic effects of adenosine 3′:5′-cyclic monophosphate. Inhibition of protein synthesis
- 1 March 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 138 (3) , 335-340
- https://doi.org/10.1042/bj1380335
Abstract
1. Evidence is presented that cyclic AMP inhibits the incorporation of l-[4,5-3H]leucine into protein in a cell-free system from rat liver. This inhibition occurs after aminoacyl-tRNA formation. 2. Microsomal fractions, isolated after the incubation of postmitochondrial supernatant with cyclic AMP and ATP, show a diminished ability to synthesize protein. Both cyclic AMP and ATP are required for this effect. 3. A possible physiological role for the anti-anabolic action of cyclic AMP is discussed in terms of the control of gluconeogenesis.Keywords
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