pH-Sensitive Hydrogel Based On A Novel Photocross-Linkable Copolymer
- 20 July 2004
- journal article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 5 (5) , 1973-1982
- https://doi.org/10.1021/bm0497567
Abstract
A pH sensitive hydrogel has been prepared by a UV irradiation technique. Starting polymer was the PHM (poly hydroxyethylaspartamide methacrylated) obtained from polyaspartamide (PHEA) partially derivatized with methacrylic anhydride (MA). This new copolymer has been further derivatized with succinic anhydride (SA) to obtain PHM-SA that has been cross-linked by UV irradiation to form a pH sensitive hydrogel. The network, recovered after washing as a powder, has been been characterized by FT-IR spectrophotometry and particle size distribution analysis. Moreover, to have information about water affinity of the prepared sample, swelling measurements have been carried out in aqueous media mimicking biological fluids. The possibility to employ the prepared hydrogel as a pH-sensitive drug delivery system (DDS) has been investigated. In particular, ibuprofen ((S)(+)4-isobutyl-α-methylphenyl-acetic acid), chosen as a model drug, has been entrapped into the PHM-SA hydrogel, and in vitro release studies have showed that its release rate depends on different swelling of the network as a function of the environmental pH.Keywords
This publication has 17 references indexed in Scilit:
- Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol)Biomaterials, 1996
- Photoscissable Hydrogel Synthesis via Rapid Photopolymerization of Novel PEG-Based Polymers in the Absence of PhotoinitiatorsJournal of the American Chemical Society, 1996
- Characterization, dynamic swelling behaviour and solute transport in cationic networks with applications to the development of swelling-controlled release systemsPolymer, 1996
- Photocrosslinked hydrogels based on copolymers of poly(ethylene glycol) and lysineJournal of Polymer Science Part A: Polymer Chemistry, 1994
- Novel biodegradable hydrogels prepared using the divinylic crosslinking agent N,O-dimethacryloylhydroxylamine. 1. Synthesis and characterisation of rates of gel degradation, and rate of release of model drugs, in vitro and in vivoJournal of Controlled Release, 1993
- Novel surface fixation technology of hydrogel based on photochemical method: Heparin‐immobilized hydrogelated surfaceJournal of Polymer Science Part A: Polymer Chemistry, 1993
- Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromersMacromolecules, 1993
- Preparation and characteristics of photocrosslinkable hydrophilic polymer having cinnamate moietyJournal of Polymer Science Part A: Polymer Chemistry, 1992
- Poly(vinyl alcohol)-heparin hydrogels as sensor catheter membranesBiomaterials, 1991
- Reaction of α,β‐poly(N‐hydroxyethyl)‐DL‐aspartamide with derivatives of carboxylic acidsJournal of Polymer Science Part A: Polymer Chemistry, 1987