A potentiometric and spectroscopic study of the interaction of angiotensin II and some of its peptide fragments with copper(II)
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 4,p. 887-894
- https://doi.org/10.1039/dt9880000887
Abstract
The synthesis is reported of the peptide fragments of angiotensin II, Asp-Arg-Val-Tyr and MeCO-Tyr-IIe-His, together with the results of a potentiometric and spectroscopic (visible, circular dichroism, and e.s.r.) study of the interaction with CuII of angiotensin II itself and the peptides. Results show that, in the pH range 6–8, CuII appears to co-ordinate to the imidazole nitrogen of the histidyl side-chain together with neighbouring deprotonated peptide nitrogens. When the pH is raised above 8 the co-ordination centre moves to give a complex resembling that found in simple peptides, i.e. through the terminal amino nitrogen and its neighbouring peptide nitrogens.Keywords
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