Platelet Function

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Abstract
Effects of Acetylsalicylic Acid on Platelet FunctionAspirin and other anti-inflammatory drugs have already been shown to interfere with the platelet-collagen reaction. In rabbits, aspirin and sodium salicylate interfere with platelet aggregation induced by collagen, antigen–antibody complexes, gammaglobulin-coated particles or thrombin.71 The release of ADP and serotonin is also suppressed. ADP-induced aggregation (that is, the primary wave) is not affected. In vivo aspirin and sodium salicylate prolong platelet survival and produce defective primary hemostasis.71 Since aspirin is known to prolong the bleeding time76 77 78 the effects of aspirin ingestion on human platelet aggregation in vitro have been investigated.75, 79 80 81 , 78 These effects may . . .