SIGNIFICANCE OF GLUCOSE LOAD IN ORAL GLUCOSE TOLERANCE TESTS

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Abstract
Blood glucose, serum insulin, growth hormone and free fatty acids (FFA) have been measured in eight young healthy subjects after oral glucose loads of 25, 50, 100 and 200 g. While the blood glucose areas only quadrupled, the insulin areas rose by a factor of 16 through the eightfold increase in oral glucose load. In the early part of the tests blood glucose was the same after high and low doses, while serum insulin was much higher after large doses. The significance of the I/G ratio in oral glucose tolerance tests is discussed in the light of the results. The serum growth hormone suppression phase increased with increasing glucose loads in male as well as in female subjects. In female subjects, however, this regular pattern was obscured by intermittent peaks. The serum FFA suppression phase also increased as glucose loads increased. Serum FFA patterns were identical in male and female subjects.