Kallikrein Therapy of Infertile Men with Varicocele and Impaired Sperm Motility: Therapie mit Kallikrein bei infertilen Männern mit Varicocele und reduzierter Spermatozoenmotilität

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Abstract
A randomized group of 65 men with oligoasthenozoospermia and left side varicocele was subjected to a control study with kallikrein. Kallikrein (600 units orally per day) was given to 38 men for a period of 3 months. The other group of 27 mean remained untreated but were followed up during the same period of time. After kallikrein treatment significant improvements in sperm quality could be observed: percentage of motile spermatozoa from 24.47 .+-. 9.01 to 35.26 .+-. 11.80, percentage of morphologically normal spermatozoa from 58.42 .+-. 5.86 to 71.05 .+-. 8.12. There was no improvement in sperm parameters in the untreated groups of men. The results suggest that kallikrein therapy is useful for those men who refuse an operative or radiologic treatment of their varicocele and also as a primary or associated therapy of patients who underwent ligature or occlusion of spermatic veins.