Initial Fall of Plasma Calcium After Intravenous Injection of Parathyroid Hormone

Publisher Website
Google Scholar
Abstract
After intravenous injection of parathyroid hormone, the plasma calcium concentration falls transiently before beginning to rise. Such an effect has previously been seen in several animals and in man, but was generally ascribed to contamination with calcitonin, which was then thought to be a hormone produced by the parathyroids. We have investigated the hypocalcemia in dogs by following the precise time course of changes in plasma calcium and phosphate after injection of calcitonin-free parathyroid hormone, and by prelabeling animals with radiocalcium. Results show that the initial hypocalcemia is due to parathyroid hormone itself and results from a rapid outflow of calcium from the blood. This evidence strengthens current theories that the action of parathyroid hormone is initiated by an increase in intracellular calcium. (Endocrinology89: 735, 1971)

This publication has 0 references indexed in Scilit: