The Histopathology of Experimental "Q" Fever in Mice

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Abstract
Histopathologic observations were made on mice killed at intervals after intranasal and intraperitoneal inoculation with a suspension of "Q" fever virus. The virus suspension was prepd. from rickettsiae growing on yolk sac and from the spleens of infected mice. In mice inoculated by both routes and using both sources of the virus, nodular and patchy granulomatous lesions composed chiefly of large mononuclear cells were found in the spleen, liver, kidneys and adrenals. Nodular and patchy areas of aplasia and degeneration were found in the bone marrow. A pneumonic reaction, characterized by early and prominent pro-liferative changes and by the predominance of large and small mononuclear cells in the exudate, was seen only in intranasally inoculated mice.

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