The correlation between drug binding to the human erythrocyte and its hemolytic activity.

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Abstract
Cationic phenothiazine derivatives, anionic anthranilic acid derivatives and fluorescent probe 1-anilino-8-naphthalene sulfonate (ANS) which had hemolytic activities were used to investigate hemolysis of human erythrocyte. The observed hemolytic activities of drugs could be divided into 2 categories: the difference of the binding activity of drugs to the erythrocyte and the difference of the membrane perturbation activity of drugs bound to the erythrocyte. The human erythrocyte had 2 kinds of binding sites for any drug used. The 1st site was saturated before hemolysis occurred and the 2nd site may be important in the hemolysis due to the drugs.