Manumycins E,F and G, new members of manumycin class antibiotics, from Streptomyces sp.
- 1 January 1994
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 47 (3) , 324-333
- https://doi.org/10.7164/antibiotics.47.324
Abstract
Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.Keywords
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