Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801)
- 1 March 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 33 (3) , 1047-1052
- https://doi.org/10.1021/jm00165a026
Abstract
Several hydrogenated derivatives of the potent NMDA antagonist 1 have been prepared and evaluated as competitive inhibitors of [3H]-1 binding. These compounds were also tested for their ability to act as noncompetitive antagonists of NMDA in vitro. These studies indicate that two aromatic rings are not strictly required for high-affinity binding or NMDA antagonism.This publication has 2 references indexed in Scilit:
- .alpha.-Effect nucleophiles: a novel and convenient method for the synthesis of dibenzo[a,d]cyclohepteniminesThe Journal of Organic Chemistry, 1988
- The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.Proceedings of the National Academy of Sciences, 1986